SF Bay Area Nanotechnology Council

IEEE

Archive for the ‘Past Events’ Category

Advances in the method of X-ray footprinting and its application to the investigation of protein interactions and conformation

Thursday, May 12th, 2022

About this event

Speaker : Corie Ralson, PhD, Facility Director, Biological Nanostructures Facility at The Molecular Foundry and Guest Scientist in Molecular Biophysics & Integrated Bioimaging

The use of X-ray footprinting mass spectrometry (XFMS) to investigate structural features and conformational changes of macromolecules in the solution state has grown substantially in the past decade and has been successfully applied to systems ranging from single domain proteins to in vivo ribonucleoprotein assemblies. The method is highly complementary to the more widely used structural elucidation techniques for biological macromolecules such as x-ray diffraction, HDX, and cryo-electron microscopy. XFMS is an in situ hydroxyl radical (•OH) labeling method; X-ray irradiation dissociates solvent water to produce hydroxyl radicals, which covalently modify side chains which are solvent accessible. More specifically, residues which are in proximity to water molecules (either bulk or bound) are modified to a greater extent than residues which are not in proximity to water. Because liquid chromatography-mass spectrometry is then used to analyze the stable covalent modifications produced, the data provide a “water map” at the single residue level, which is then used to determine sample conformation. In this talk, I will describe the XFMS method, its advantages and disadvantages relative to other methods, recent technological advances in the method, and some recent exciting examples of structural information obtained on protein systems using the method.

Biological Macromolecules' structure; XFMS investigation image

Corie Ralston holds a B.S. in Physics from the University of California at Berkeley, and a Ph.D. in Biophysics from the University of California at Davis. She completed a post-doctoral fellowship at Brookhaven National Laboratory during which she helped develop the method of X-ray footprinting as a structural investigation technique for proteins and nucleic acids. In addition to being the Facility Director of of the Biological Nanostructures facility at the Molecular Foundry, she holds a guest appointment in the Molecular Biophysics and Integrated Bioimaging division at Berkeley Lab, and is actively developing the method of X-ray footprinting at the Advanced Light Source synchrotron.

In-Memory Computing Hardware AcceleratorsCo-designing devices, circuits and architectures for explainable machine learning and pattern matching applications

Sunday, May 1st, 2022

 Dr. Cat Graves,Principal Research Scientist at Hewlett Packard Labs
Cost: Free, but registration is required. Register: Here
     Registered attendees will receive an email with a link for the Zoom meeting

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Wed April 20 – Agenda (California Time)
11:30 AM – Check-in
12:00 PM – Announcements and Speaker Introduction
12:10 – 1:30 PM –  Seminar and Q&A
 
           
Abstract: 
The dramatic rise of data-intensive workloads has revived special-purpose hardware for continuing gains in computing performance. Several promising special-purpose approaches take inspiration from the brain, which outperforms digital computing in power and performance in key tasks such as pattern matching. One brain-inspired architecture called “in-memory computing” significantly reduces data movement and has been shown to improve performance in CMOS ASIC demonstrations. However, these approaches still suffer from low power efficiency. Emerging non-volatile memories are a highly attractive alternative for low-power and high-performance in these architectures. Originally developed as digital (binary) non-volatile memories, many of these devices have a highly tunable analog resistances which are well-matched to in-memory computing architectures. I will review our team’s recent work using crossbar and content addressable memory (CAMs) circuits to accelerate important computing workloads in machine learning, complex pattern matching and optimization. I will also discuss our team’s recently invented analog CAM circuit targeted to accelerate interpretable machine learning models. Our work spans co-design from circuits and devices to algorithms and architectures to enable low power, high-throughput computation for important computing workloads.

                        
 Dr. Cat Graves is a Principal Research Scientist at Hewlett Packard Labs developing analog and neuromorphic computational accelerators which leverage emerging devices such as resistive RAM (RRAM) for high energy efficiency and throughput compared to general-purpose digital approaches in data-centric domains. Some of her previous work utilized multilevel analog resistive RAM devices to natively perform matrix multiplication within crossbars, accelerating a core computation of wide-ranging applications from neural networks to signal processing. Currently, she leads a research team exploring uses of RRAM-based and analog associative memory circuits for accelerating diverse computational models, including tree-based ML models and finite automata processing for network security and genomics applications. Cat was awarded Silicon Valley Intellectual Property Law Association (SVIPLA) Inventor of the Year in 2021 for her co-invention of analog content addressable memories. Cat received her Ph.D. in Applied Physics from Stanford University studying ultrafast magnetism for future magnetic memory technologies while an NSF Graduate Research Fellow. She has published over 35 peer-reviewed papers, three book chapters, and has been awarded 14 US patents.

Affordable Nano Solutions for Covid Treatment

Tuesday, March 1st, 2022
Prof. Jayakumar Rajadas, Director of the Regenerative Biomaterials Lab at Stanford

Cost: Free, but registration is required. Register: Here
     Registered attendees will receive an email with a link for the Zoom meeting

Thurs Feb 24 – Agenda (California Time)
11:30 AM – Check-in & Nano Journal Club:
     Review of Oxygenation with Nanobubbles: Possible Treatment for Hypoxic COVID-19 Patients
     Come prepared to discuss!
12:00 PM – Announcements and Speaker Introduction
12:10 – 1:30 PM –  Seminar and Q&A
 
From the early days of this pandemic until now, the reality of still no medication being readily available which can guarantee therapeutic and potentially lifesaving efficacy in all of the stages and diverse pathological manifestations of this novel coronavirus has inflicted drastic consequences upon the world. We have developed two drugs in vitro showing great promise for the successful treatment of acute, moderate and severe COVID-19 as well as persisting immune-mediated consequences with respect to advanced pharmacokinetics. The objectives of our approach and the underlying mechanisms are manifold, strategically aimed at preventing viral replication, concomitantly reducing the inflammation caused by this devastating and highly infectious disease and improving the antibody response to vaccines. Additionally, we also developed a partially repurposed nano technology to improve oxygen saturation in acute respiratory distress syndrome (ARDS) as a result of COVID-19.

Professor Jayakumar Rajadas is the author of 237 peer reviewed publications, has developed 82 patents, discovered the therapeutic effects of Disulfiram and Azlocillin for the treatment of persistent Lyme disease and is currently researching and developing solutions for COVID-19. Other projects of his focus use biophysical approaches such as AFM, fluorescence, and NMR to work on the molecular mechanisms of protein-initiated neurodegenerative disorders involved in the pathology of Alzheimer’s and Lyme disease. Furthermore, he is also known for his development of a unique and successful implantable biomaterials commercially available all over the world . He is the founding director of the ADDReB Laboratory of Cardiovascular Institute at Stanford School of Medicine. He is a trained chemist with a Ph.D. in Biophysical Chemistry from the Indian Institute of Technology, Chennai , India.

High-yield growth of aligned carbon nanotubes for applied energy applications

Thursday, July 8th, 2021

Eric Meshot, Staff Scientist, Lawrence Livermore Nat’l Lab

Tues July 20 – Agenda (California Time)
11:30 AM – Check-in & Nano Journal Club:
                            Carbon Nanotubes and Related Nanomaterials – Come prepared to discuss!
12:00 PM – Announcements and Speaker Introduction
12:10 – 1:30 PM –  Seminar and Q&A

Cost: Free, but registration is required. Register: Here
     Registered attendees will receive an email with a link for the Zoom meeting

  Advanced applications of vertically aligned single-walled carbon nanotube (SWCNT) “forests” require synthesis processes that minimizes nanotube diameter while maximizing number density across substrate areas exceeding centimeter scale. To address this need, we synthesized SWCNT forests on full silicon wafers with notable reproducibility and uniformity, and co-optimized growth for small diameters and high densities across large areas to access new territory in this 3D parameter space. We mapped the spatial uniformity of key structural features using Raman microscopy, X-ray scattering, and Rutherford backscattering spectrometry. Mass conversion rates from gas-phase hydrocarbon precursors to solid SWCNT product were high and remarkably invariant for different nano-catalyst compositions and densities, far exceeding typical lab-scale, benchtop reactors. Routine and robust manufacture of these high-quality materials at a practical scale unlocked a portfolio of high-performance applications, including energy storage devices, electronic gas sensors, optical metamaterials, twist-spun fibers, and 3D-printed composites.

Read More:
     High-yield growth kinetics and spatial mapping of single-walled carbon nanotube forests at wafer scale
     Quantifying the Hierarchical Order in Self-Aligned Carbon Nanotubes from Atomic to Micrometer Scale

 Dr. Eric Meshot (meh-SHOHT) is a staff scientist and principal investigator (PI) at Lawrence Livermore National Laboratory (LLNL) in the Physical and Life Sciences Directorate. He leads interdisciplinary teams geared toward connecting synthesis, structure, and performance in nanostructured carbon materials for a range of applications. Before joining LLNL in 2013, he was awarded a postdoctoral fellowship through the Belgian American Educational Foundation (BAEF) to investigate carbon nanostructures in electronics at imec in Leuven, Belgium. He holds the B.S. degree in engineering physics from the University of California at Berkeley (Go Bears!). He earned M.S.E degrees in both materials science and engineering and mechanical engineering before obtaining the Ph.D. degree in mechanical engineering in 2012 – all from the University of Michigan (Go Blue!). In his spare time, he enjoys playing basketball, chess, snowboarding, biking with his family, and relaxing at the beach.

Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube Based Near-Infrared Nanosensors

Tuesday, May 25th, 2021

Professor Markita Landry, Chemical and Biomolecular Engineering,  UC Berkeley

Thurs June 17 – Agenda (California Time)
1:30 PM – Check-in & Nano Journal Club:
Diagnostics for SARS-CoV-2 Infections – Come prepared to discuss!
     2:00 PM – Announcements and Speaker Introduction
     2:10 PM – 3:00 PM : Seminar
Cost: Free, but registration is required

Register on Eventbrite: Here
     Registered attendees will receive an email with a link for the Zoom meeting

     The global SARS-CoV-2 coronavirus pandemic has led to a surging demand for rapid and efficient viral infection diagnostic tests, generating a supply shortage in diagnostic test consumables including nucleic acid extraction kits. Here, we develop a modular method for high-yield extraction of viral single-stranded nucleic acids by using ‘capture’ ssDNA sequences attached to carbon nanotubes. Target SARS-CoV-2 viral RNA can be captured by ssDNAnanotube constructs via hybridization and separated from the liquid phase in a single-tube system with minimal chemical reagents, for downstream quantitative reverse transcription polymerase chain reaction (RT-qPCR) detection. This nanotube-based extraction method enables 100% extraction yield of target SARS-CoV-2 RNA from phosphate buffered saline in comparison to ~20% extraction yield when instead using a commercial silica-column kit.
     Notably, carbon nanotubes enable extraction of nucleic acids directly from 50% human saliva, bypassing the need for further biofluid purification and avoiding the use of DNA/RNA extraction kits. Carbon nanotube-based extraction of viral nucleic acids facilitates high-yield and high-sensitivity identification of viral nucleic acids such as the SARS-CoV-2 viral genome with reduced reliance on reagents affected by supply chain obstacles.
     We additionally discuss a carbon nanotube-based near-IR nanosensor for detection of active SARS-CoV-2 infections, in which the presence of the SARS-CoV-2 spike protein elicits a robust, two-fold near-IR nanosensor fluorescence increase within 90 min of spike protein exposure. We characterize the nanosensor stability and sensing mechanism and passivate the nanosensor to preserve sensing response in saliva and viral transport medium. We further demonstrate that these ACE2-SWCNT nanosensors retain near-IR detection capacity in a surface-immobilized format, exhibiting a 73% fluorescence turn-on response within 5 s of exposure to 35 mg/L SARS-CoV-2 virus-like particles. Taken together, our efforts can help increase the sensitivity of existing qPCR-based tests and provide orthogonal methods of identifying active CoV2 infections.

Read More: Rapid SARS-CoV‑2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors

     

     Markita Landry is an assistant professor in the department of Chemical and Biomolecular Engineering at the University of California, Berkeley. She received a B.S. in Chemistry and a B.A. in Physics from the University of North Carolina at Chapel Hill, a Ph.D. in Chemical Physics and a Certificate in Business Administration from the University of Illinois at Urbana-Champaign, and completed an NSF postdoctoral fellowship in Chemical Engineering at the Massachusetts Institute of Technology.
     Her current research centers on the development of synthetic nanoparticle-polymer conjugates for imaging neuromodulation in the brain, and for the delivery of genetic materials into plants. The Landry lab exploits the highly tunable chemical and physical properties of nanomaterials for the creation of bio-mimetic structures, molecular imaging, and plant genome editing. She is also on the scientific advisory board of Terramera and on the scientific advisory board of Chi-Botanic. She is a recent recipient of over 20 early career awards, including awards from the Brain and Behavior Research Foundation, the Burroughs Wellcome Fund, the DARPA Young Investigator program, the Beckman Young Investigator program, the Howard Hughes Medical Institute, the NSF CAREER award, is a Sloan Research Fellow, an FFAR New Innovator, and is a Chan Zuckerberg Biohub Investigator.


Would your company sponsor the Nanotechnology Council?
The investment required would be a very modest % of your marketing budget! Contact: Glenn Friedman

May 12 Nano Forum: ActiveCopper™ attacks Covid

Monday, May 3rd, 2021

Ultra-Active Antimicrobial Copper Surfaces, Self-Sterilizing in 30-60 sec: Engineered Copper at the Nanoscale

Dr. Alfred Zinn, Founder and CTO at Kuprion Inc.

Wed May 12 – Agenda (California Time)
11:30 AM – Check-in & Nano Journal Club:
A materials-science perspective on tackling COVID-19 – Come prepared to discuss!
     12:00 PM – Announcements and Speaker Introduction
     12:10 PM – 1:00 PM : Seminar
Cost: Free, but registration is required

Register on Eventbrite: Here
     Registered attendees will receive an email with a link for the Zoom meeting

     The coronavirus disease 2019 (COVID-19) has created an acute worldwide demand for sustained broadband pathogen suppression in households, hospitals, and public spaces. The US recently passed a new sad milestone of 500,000 deaths due to COVID-19, the highest rate anywhere in the world. In response, we have created a rapid-acting, self-sterilizing copper material capable of killing SARS-CoV-2 and many other microbes in seconds. The highly active material destroys pathogens faster than any conventional copper configuration. The material maintains its antimicrobial efficacy over weeks and is shelf stable. We have performed rigorous testing in accordance with guidelines from U.S. governing authorities and believe that the material could offer broad spectrum, non-selective defense against most microbes via integration into masks and other protective equipment. The presentation will provide a detailed view into the “inner” workings of the material including the underlying mechanical details that make this high efficacy possible.

     

     Dr. Alfred Zinn is founder and CTO of Kuprion Inc., a materials company principally engaged in the manufacture and application of engineered copper materials for a wide variety of applications such as surface mount technology, packaging, printed circuit board assembly, printed electronics, 3D printing, injection molding and many thermal applications with special focus on copper-based nanomaterials. The latter are fused to bulk copper to take advantage of the low processing temperatures, and the high electrical and thermal conductivity of bulk copper. Since the onset of the Covid-19 pandemic, Dr. Zinn and the Kuprion team have been investigating ActiveCopper (aCu) as a powerful antimicrobial. aCu has been successfully tested against Gram-negative and positive bacteria, non/enveloped viruses including SARS-CoV-2, and multiple resistant strains of bacteria (“superbugs”). In all instances it kills pathogens in 1 minutes or less, which is an unprecedented level of efficacy for copper. With these extraordinary findings, Dr. Zinn has submitted the material for EPA registration for incorporation into PPE such as masks, gloves, and surface coatings.

Alfred received his Doctor of Science degree in Chemistry in 1990 from the Philipps University, Marburg, Germany. Prior to his current position, Dr. Zinn was a Lockheed Martin Fellow at the Advanced Technology Center (ATC) of the Lockheed Martin Space System Company, in Palo Alto, CA. He holds over 40 patents in materials, structures and processing technologies and THz technology. He has authored or coauthored over 30 archival journal publications, including book chapters in “The Chemistry of Metal CVD” as well as the “Encyclopedia of Inorganic Chemistry.” Over the past two decades, he has presented his technical results and accomplishments at many national and international Conferences.


Origin Stories – Exploring Entrepreneurship

Thursday, April 15th, 2021

Details

Our most popular event series: Several CEO/Founders discuss the technology and business aspects of building a successful company based on nanotechnology. Cost: Free!

Registration: https://www.eventbrite.com/e/origin-stories-exploring-entrepreneurship-tickets-148108094297

Wednesday, April 21, 2021
3:30 PM to 7:00 PM PDT

Zoom Meeting

Agenda (California Time)

3:30 – 4:00 pm – Check-in & Nano Journal Club**

4:00 – 4:15 pm – Welcome

4:15 – 5:20 pm – Lightning Presentations by Company Founders

5:25 – 6:45 pm – Panel Discussion – Glenn Friedman, moderator

Nano Journal Club: During the check-in period, Lincoln Bourne will lead a discussion of: Nanotechnology for Virus Treatment – a review paper that covers “Recent developments in antiviral nanotherapeutics and… a perspective on the application of nanotechnology to the SARS-CoV-2 outbreak and future virus pandemics”. The senior author, Liangfang Zhang, is one of the presenters for the main program.

Combating the COVID Pandemic in India: A Genomics Approach

Thursday, March 11th, 2021

Dr. Jyoti Yadav, Sr. Pr. Scientist at the Institute of Genomics and Integrative Biology (IGIB), Delhi, INDIA

Dr. Jyoti Yadav is a Sr. Pr. Scientist at the Institute of Genomics and Integrative Biology (IGIB) in Delhi. IGIB is a constituent laboratory of CSIR, Under Ministry of Science and Technology, India. Dr. Yadav is an alumnus of IIT Kanpur, had worked as a visiting Faculty in Japan’s Tohoku University and was a postdoctoral researcher at Johns Hopkins School of Medicine, USA.

Wed March 24
     
5:30 PM: Registration & Nano Journal Club
     6:00 PM: Speaker Introduction and Announcement
     6:10 PM – 7:00 PM: Seminar
Cost: Free, but registration is required

Register on Eventbrite: Here
     Registered attendees will receive an email with a link for the Zoom meeting

New! Journal Club: During the registration period, Lincoln Bourne will lead a discussion of selected abstracts from the most recent Meta conference, Lisbon 2019.

Abstract

The beginning of 2020 was marked with stories of a mysterious virus overpowering all possible human efforts to combat it. In no time, it reached India, Delhi. Amongst all, scientists tirelessly looked for solutions to mitigate the problem. The solutions changed as time progressed, but the spirit never changed. Scientists at IGIB provided different solutions at different time points of the pandemic. How genomics contributed in combating the pandemic in India is the story I am going to talk about.


Announcement: Now forming a new IEEE Nanotechnology Technical Committee for the promotion of technological innovation and excellence in quantum, neuromorphic and unconventional computing. The purpose is to face societal challenges in these areas through participations in NTC conferences, publications and other outreach and education activities. Contact Giovanni Finocchio or Kerem Camsari

3D Interferometry and Nanomechanics – Electronics, Face Masks and More

Thursday, February 11th, 2021

Kurt Rubin, KLA Tencor

Tues Feb 16
     11:30 am – Sign-ins begin
     12:00 pm – Program starts
       1:30 pm – Event ends
Cost: Free, but registration is required

Register on Eventbrite: Here
     Registered attendees will receive an email with a link for the Zoom meeting

     3D optical profiling is a noncontact, high-resolution measurement and visualization technique used to measure the topography and geometry of devices and materials. Capabilities of commercial 3D interferometry systems have steadily improved; today, they can measure vertical nano- and microtopography spanning Ångstroms to many millimeters in length scale. True Color imaging, developed by KLA, provides additional understanding that is complimentary to topography. Advances in optomechanical hardware, optics, electronics, and software now make it possible to create economical precision 3D interferometric measurement systems, enabling 3D profiling to help a broader range of industrial and scientific applications.
     This talk provides an example of how the capabilities of this new generation of 3D optical measurements can be applied to the fields of printed and flexible electronics. Flexible electronics is characterized by a rich and diverse set of functions, device topographies, fabrication technologies, and various materials (conducting, insulating, dielectric, etc.), which have complex surface structures with diverse optical properties. Multiparameter printed arrays on flexible substrates can be used for sensing humidity, temperature, and mechanical strain, as well as for thermoelectric generators and many other purposes, all of which have performance dependencies upon geometry and fabrication process.
    Ultraviolet germicidal irradiation (UVGI) N95 filtering facepiece respirator (FFR) treatment is considered an effective decontamination approach to address the supply shortage of N95 FFRs during the ongoing Covid-19 pandemic. We investigated the nanomechanical and non-contact 3D optically-measured topographic properties of filtration fibers that have been exposed to different doses of UVC radiation. UVC exposure was shown to decrease both Young’s modulus (E), hardness (H) and fiber width, as measured on individual polypropylene (PP) fibers. Our results also show that the PP microfiber layer loses its strength when N95 respirators are exposed to an accumulated UVC dose during the process of decontamination, and the PP fiber width also exhibits a logarithmic decrease during UVC exposure. The nanoscale measurement results on individual fibers suggest that maximum cycles of UVC disinfection treatment should be limited due to excessive accumulated dose, which has the potential to decrease the fiber breaking strength.
     This talk will discuss examples of how optical and nanomechanical characterization can improve understanding of devices and materials, including the above topics, and more.

Read More:
     3D optical interferometry with True Color visualization advances understanding of flexible electronics
     Effect of Ultraviolet C Disinfection Treatment on the Nanomechanical and Topographic Properties of N95 Respirator Filtration Microfibers

               

     Kurt Rubin is an Applications Development Engineer at KLA Instruments where he focuses on advanced optical and electrical measurement and modeling. He has an extensive background in the invention of new optical, electrical and magnetic devices, materials and the development of new processes to fabricate them. He is an inventor of fundamental technology underlying multilayer optical storage and high-speed reversible memories. He holds 60 issued patents and degrees in physics and materials science from MIT, University of Washington and Stanford University.



TheIEEE Nanotechnology Council provides a forum for leading researchers and companies to discuss their work, along with networking opportunities for local scientists and engineers

In 2014, 2016, and again in 2019, the Nanotech Council was awarded Best Chapter for IEEE Region 6, out of of 200+ chapters in 12 states
In 2014, 2017, and again in 2019, the Council was awarded Nanotech Chapter of the Year by the IEEE Nanotech Council (worldwide)

Photos from past events posted: Here

Nov 12th, 2020: Online Symposium on Quantum Computing: Devices, Challenges and Applications

Wednesday, October 21st, 2020

IEEE SFBA Nanotechnology Council presents a symposium on Zoom! Join us for this one-day virtual conference!

When: Thurs Nov 12 – 8:30 AM to 3:30 PM Pacific Time (9am start)
Cost:
$5 – with discounts available (Limited free tickets for Students and Unemployed/In-Transition/Retirees)

Online Event! Register HERE ! Registered attendees will receive an email with a link for the Zoom meeting

Quantum Computing: Devices, Challenges and Applications

The conference brings together leading researchers at the cutting edge of Quantum Computing technology from academia, government lab and industry. Topics covered will include various approaches to building quantum devices including superconducting Qbits (Google, IBM), adiabatic annealing (DWave\NASA Ames), and Quantum Photonic approaches such as defects in semiconductors and single atom Qubits using ultra cold atoms (Stanford\UC Berkeley).

Apart from discussions on different device approaches to harnessing information based on the interactions of light and electrons, the conference will also cover important computational challenges in this field. Topics covered will include designing effective quantum algorithms, quantum supremacy, scalability, quantum-inspire. We will strive to provide an effective forum for conference participants to network and actively engage with the speakers.

Our Lineup (for full abstracts and bios, click here!) :