1C – Microbubbles and Nanodroplets for Biomedical Ultrasound Applications: Design Principles and Methods

Title1C - Microbubbles and Nanodroplets for Biomedical Ultrasound Applications: Design Principles and Methods
InstructorMark Borden, University of Colorado, USA and Hendrik Vos, Erasmus Medical Center, Netherlands
Overview of topics covered

  • Design and synthesis of microbubbles

  • Size distribution measurements

  • Targeting for molecular imaging

  • Drug loading

  • Linear and nonlinear oscillations

  • Imaging

  • Mechanical interactions

  • Destruction and shedding

TimeMonday, October 22
AbstractMicrobubbles are used in ultrasonics as contrast agents, molecular imaging probes and targeted drug delivery vehicles. This short course will provide an overview of the basic chemistry and physics of microbubbles relevant to these applications. The first part of the course will focus on practical tips to help you design and synthesize your own microbubbles, including a review of current methods for loading targeting ligands and drugs onto the microbubble shell. The second half will review the basic physics of microbubble oscillations and phenomena related to imaging and drug delivery, including high-frame-rate optical and acoustical recordings from both in vitro and in vivo experiments.
Short CV of Instructor Mark Borden is an Associate Professor of Mechanical Engineering, Materials Science & Engineering and Bioengineering at the University of Colorado. He received the B.S. in Chemical Engineering from the University of Arizona in 1999 and the Ph.D. in Chemical Engineering from the University of California Davis in 2003. He then worked as a postdoctoral researcher in Biomedical Engineering at UC Davis and visiting scientist in Radiology at the Arizona Cancer Center. He was an Assistant Professor of Chemical Engineering at Columbia University from 2007-2010 before taking his current position at the University of Colorado, Boulder. He has published over 80 journal articles and book chapters, as well as 7 issued patents, on microbubbles and their biomedical applications. He currently serves as Associate Editor of the Journal of Membrane Biology, member of the scientific board for the European symposium on Ultrasound Contrast Imaging, and member of the NIH Biomaterials and Biointerfaces (BMBI) study section. His honors include an NSF CAREER Award and the James D. Watson Investigator Award.

Hendrik J. Vos is Assistant Professor at Erasmus MC, Rotterdam, the Netherlands, in high frame rate echography. He received the M.Sc. degree with honors in Applied Physics from Delft University of Technology, The Netherlands in 2004. He received the Ph.D. in Biomedical Engineering from Erasmus MC in 2010, in optical and acoustic characterization of ultrasound contrast microbubbles. He has also worked as a Postmaster Researcher with the University of Florence, Italy, and as an industrial contract researcher on ultrasonic monitoring solutions and microbubble detection systems. His current research is in biomedical imaging and related subclinical and clinical studies in its various aspects: 2-D and 3-D transducers and beamforming, contrast microbubble imaging, ultrafast Doppler, and cardiac shear waves. He has published over 40 journal articles and book chapters on biomedical imaging. He also is co-director of the annual European Symposium on Ultrasound Contrast Imaging, Rotterdam, and faculty member of the International Bubble Conference, Chicago, which are both affiliated to the International Contrast Ultrasound Society (ICUS)