The International Conference on Innovations in Intelligent Systems: Advancements in Computing, Communication, and Cybersecurity (ISAC3-2025) will provide a platform for researchers and practitioners to collaborate on advancements in intelligent computing, communication, and cybersecurity. In the era of data-driven technologies, ISAC3-2025 will address the significance of effective and secure information handling across various domains. Key themes include; (1) Artificial Intelligence and Machine Learning, (2) Data Science and Health Informatics, (3) Advances in Networking, Internet of Things and 5G, (4) Information Security and, (5) Emerging Technologies and Applications.